UPS - LEIDER IST IHR BROWSER VERALTET!

Um zukunftsfähig zu sein, wurde unsere aktuelle Webseite für die neuesten Technologien entwickelt.
Daher können bei alten Browsern leider Probleme auftreten.
Damit die neue Börse-Online-Seite richtig funktioniert und Spaß macht, empfehlen wir Ihnen einen dieser aktuellen und kostenlosen Browser herunterzuladen:

DAX 15.814 2,8%  MDAX 34.839 2,5%  Dow 35.645 1,2%  Nasdaq 16.272 2,7%  Gold 1.785 0,4%  TecDAX 3.892 3,7%  EStoxx50 4.276 3,4%  Nikkei 28.456 1,9%  Dollar 1,1266 -0,2%  Öl 75,1 2,1% 

Cel-Sci, Biotech Chance

Seite 7 von 15
neuester Beitrag: 30.11.21 19:05
eröffnet am: 05.06.19 09:31 von: Mr.Boombas. Anzahl Beiträge: 354
neuester Beitrag: 30.11.21 19:05 von: hero_of_the. Leser gesamt: 70215
davon Heute: 74
bewertet mit 4 Sternen

Seite: Zurück 1 | ... | 4 | 5 | 6 |
| 8 | 9 | 10 | ... | 15  Weiter  

19825 Postings, 2223 Tage hero_of_the_dayMan erkennt hier schon

 
  
    
3
20.10.20 17:47
ein gewisses Schema. Wenn wir mal auf das Jahr zurückblicken ging es immer mal zwei Schritte vorwärts und einen zurück. Nur nebenbei, auch so läßt sich Geld verdienen. Wer das erkennt und so durchziehen kann, warum nicht!  

1645 Postings, 3248 Tage Mr.BoombasticJa das stimmt

 
  
    
1
20.10.20 19:33
Aber mir ist das rein und raus gehen hier einfach zu heiß. Jedenfalls zum jetzigen Zeitpunkt. Habe das hin und wieder mal im Bereich zwischen 2 und 4 gemacht. Aber am Ende muss ich sagen, es wäre besser gewesen einfach immer drin geblieben zu sein.  

19825 Postings, 2223 Tage hero_of_the_dayNee, hast schon Recht

 
  
    
3
20.10.20 19:52
Ganz so einfach ist es auch wieder nicht und ob man dann immer den richtigen Zeitpunkt beim Aus- und Einstieg trifft, ganz zu schweigen vom Zeitaufwand. Es gibt ja auch noch ein Leben neben der Börse, wer ist schon immer online?  

13 Postings, 650 Tage DaBrainhui langsam werde ich unruhig..

 
  
    
03.11.20 19:45
Schon Wahnsinn, wie diese Aktie schwankt. Völlig normal, ich weiß. Aber dieses mal habe ich irgendwie ein ungutes Gefühl..

Was glaubt ihr, wie die kurzfristige Entwicklung ist bzw was ist eure Einschätzung?
 

19825 Postings, 2223 Tage hero_of_the_dayDu musst tun, was du tun musst!

 
  
    
5
03.11.20 23:54
Diese Entscheidung wird dir niemand abnehmen können, halte durch, oder drück den Button.
Es ist hier eigentlich alles gesagt worden, einfach abwarten, die Tage sind gezählt. Für mich persönlich gilt, bei diesen Kursen pack ich eher weiter drauf als auch nur eine Aktie abzugeben. Keine Handlungsempfehlung!!  

19825 Postings, 2223 Tage hero_of_the_dayInstitutionelle Investoren

 
  
    
5
13.11.20 21:51
Auch große Adressen glauben an den Erfolg : https://fintel.io/so/us/cvm  

1645 Postings, 3248 Tage Mr.Boombastic@hero

 
  
    
1
22.11.20 21:05
Ja sehr interessant. Mal schauen ob es kommende Woche anzieht. Ich gehe davon aus. Der Freitag war auch schon nicht schlecht.

 

19825 Postings, 2223 Tage hero_of_the_dayDas Finale naht

 
  
    
2
22.11.20 21:34
Ich bin guter Dinge, vieles spricht für einen großen Erfolg. In diesen bescheidenen Zeiten ein Medikament was den Krebs in die Schranken weist wird zugelassen, das wäre der absolute Bringer!  

1645 Postings, 3248 Tage Mr.Boombasticshort interest

 
  
    
1
26.11.20 10:53
Die neuen Zahlen sind veröffentlicht. Das Shortvolumen hat erneut zugenommen. Und zwar um rund 15%. Somit jetzt über 10 Mio. Aktien Short! Wahnsinn!
Positiv dass sich der Kurs trotzdem so gut hält.
Ich freue mich auf einen gigantischen Squeeze :)  

1645 Postings, 3248 Tage Mr.BoombasticAuch LEAPS ist noch ein Thema....

 
  
    
1
01.12.20 16:31
liest sich recht gut!

CEL-SCI?s LEAPS Peptides Demonstrate Clear Survival Benefit as a Treatment for COVID-19 in Preclinical Studies

Source: Business Wire
LEAPS targets the non-mutating part of the SARS-CoV-2 virus and works through activating a T cell response possibly offering long term benefits

CEL-SCI Corporation (NYSE American: CVM) announced today its LEAPS COV-19 peptides, delivered as a therapeutic treatment following SARS-CoV-2 virus challenge, achieved a 40% survival rate in transgenic mouse models as compared to 0% survival in the two control groups in studies conducted at the University of Georgia Center for Vaccines and Immunology.

Scientists at the University of Georgia working in conjunction with CEL-SCI?s scientific team conducted a challenge study in human(h) ACE2 receptor transgenic mice infected with a dose of SARS-CoV-2 (the causative agent of COVID-19 disease) virus sufficient to cause death in all animals within 8 days. This transgenic animal model is useful to study COVID-19 disease because the mice express the molecule that provides entry for the SARS-CoV-2 virus into human cells. Virus infection is optimized in this animal model providing an ideal system to determine vaccine induced immune protection or therapy against a SARS-CoV-2 infection of humans.

The animals were therapeutically treated with CEL-SCI?s LEAPS COV-19 peptides one day after infection with a lethal dose of SARS-CoV-2. Of the LEAPS treated mice, forty percent (40%) were alive, recovering and regained lost weight, attaining > 90% of their starting weight, by the study?s end. In contrast, mice in the two control groups lost 20% or more of their body weight by day 8 and all of them died between day 5 and day 8 post challenge. The success of this therapy was statistically significant at a 95% level.

An additional study conducted using LEAPS as a vaccine to prevent disease resulted in similar findings to the above described study, but with a slightly lower level of statistical significance. In this study, the Human(h) ACE2 transgenic mice were dosed twice with the LEAPS conjugate 28 and 14 days prior to being challenged with a lethal dose of SARS-CoV-2 virus.

?We are highly encouraged by these results, which clearly show our LEAPS COV-19 peptides produced a survival benefit in a very credible animal model, which mimics the virus? effects in humans. A critical benefit of LEAPS?s mechanism of action is its focus on highly conserved portions within the nucleoprotein of the virus. This may become very important as mutations in SARS-CoV-2 that could limit a vaccine or treatment induced protection have already been reported. While LEAPS can potentially work as a vaccine, the greater need though is to provide better treatment for the acute disease stage and also for the longer-term complications of the virus. Helping those patients is our goal,? stated CEL-SCI CEO Geert Kersten.

Daniel Zimmerman, Ph.D., Senior VP of Research Cellular Immunology at CEL-SCI and discoverer of the LEAPS technology added, ?Based on prior animal studies we also know that LEAPS peptides can reduce inflammation and cytokine storm. We think it is likely to have a similar effect on the cytokine storm that causes severe systemic COVID-19 disease. Our next step is to leverage the findings from these two animal studies into future studies that will optimize treatment dosing and test additional LEAPS peptides as a therapy.?

Background on LEAPS and its Relevance to COVID-19

CEL-SCI?s goal is to develop an immunotherapy with the potential to treat the SARS-CoV-2 virus using its patented LEAPS peptide technology. The LEAPS peptides utilize conserved regions of SARS-CoV-2 proteins to stimulate protective antibody and cell mediated T cell responses to reduce viral load and systemic inflammatory immune responses. The LEAPS peptide technology can be used to construct immunotherapeutic peptides that exhibit both antiviral and anti-inflammatory properties at the same time. Consequently, these products not only target the virus infection against which they are directed, but also elicit the appropriate protective response(s) against it, without exacerbating an overly active inflammation.

CEL-SCI?s studies are utilizing the LEAPS peptide approach, which is unique in its proven ability in animals to elicit both a cell mediated antiviral response and an anti-inflammatory immunomodulating response by activating CD8 T lymphocytes. Previous studies showed that LEAPS immunogens can prevent lethal infection by herpes simplex virus (HSV) and stop the inflammatory disease progression of rheumatoid arthritis in animal models. LEAPS peptides against HSV demonstrated that the T cell response was sufficient to prevent viral disease, and if there was residual virus production, anti-viral antibody was generated to further control the spread of the virus.

The LEAPS-COV-19 peptide conjugates are directed towards antigens within the NP protein of SARS-Cov-2, the causative agent of COVID-19. These conjugates elicit cytolytic T cell responses to virus infected cells and immunomodulating responses. Unlike glycoprotein spike antigens, which are utilized in antibody-based vaccines, the T cell antigens are less variable between viral strains and less likely to change in response to antibodies elicited by prior infection or other vaccines. Cytolytic T cell responses attack the virus infected cellular ?factories? within the infected host in order to eliminate the source of virus and help subdue the infection.

Ligand Epitope Antigen Presentation System (LEAPS) platform technology has demonstrated in several animal models the ability to design antigen-specific immunotherapeutic peptides that preferentially direct the immune response to a cellular (e.g., T cell), humoral (antibody) or mixed response and are also capable of enhancing important T-regulatory (Treg) responses. Therefore, the LEAPS technology provides the opportunity to develop immunotherapeutic products for diseases for which disease associated antigenic peptide(s) sequences have already been identified, such as: a number of infectious diseases, some cancers, autoimmune diseases (e.g., RA), allergic asthma and allergy, select CNS diseases (e.g., Alzheimer's) and the SARS-Cov-2 virus.

The Company's LEAPS technology is currently also being developed as a therapeutic vaccine for rheumatoid arthritis and is supported by $1.5 million grant for IND enabling studies from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

About CEL-SCI Corporation

The Company?s LEAPS technology is currently being developed for rheumatoid arthritis and as a potential treatment for COVID-19 infection/disease.

CEL-SCI is also close to the readout for a very large head and neck cancer study using another immunotherapy product called Multikine*. CEL-SCI believes that boosting a patient?s immune system while it is still intact should provide the greatest possible impact on survival. Therefore, in the Phase 3 study CEL-SCI treated patients who are newly diagnosed with advanced primary squamous cell carcinoma of the head and neck with the investigational product Multikine first, BEFORE they received surgery, radiation and/or chemotherapy. This approach is unique. Most other cancer immunotherapies are administered only after conventional therapies have been tried and/or failed. Multikine (Leukocyte Interleukin, Injection), has received Orphan Drug designation from the FDA for neoadjuvant therapy in patients with squamous cell carcinoma (cancer) of the head and neck.

CEL-SCI believes that this Phase 3 study is the largest Phase 3 study in the world for the treatment of head and neck cancer. Per the study?s protocol, newly diagnosed patients with advanced primary squamous cell carcinoma of the head and neck were treated with the Multikine treatment regimen first - for 3 weeks prior to receiving the Standard of Care (SOC), which involves surgery, radiation or concurrent radiochemotherapy. Multikine is designed to help the immune system ?see? the tumor at a time when the immune system is still relatively intact and thereby thought to better be able to mount an attack on the tumor. The aim of treatment with Multikine is to boost the body?s immune system prior to SOC to attack the cancer. The Phase 3 study is fully enrolled with 928 patients and the last patient was treated in September 2016. To prove an overall survival benefit, the study requires CEL-SCI to wait until 298 events have occurred among the two main comparator groups. This study milestone occurred in late April 2020.

The Company has operations in Vienna, Virginia, and near/in Baltimore, Maryland.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements with respect to Multikine and the Phase 3 clinical trial of Multikine in patients with advanced primary squamous cell carcinoma of the head and neck. When used in this press release, the words "intends," "believes," "anticipated," "plans" and "expects," and similar expressions, are intended to identify forward-looking statements. Such statements are subject to risks and uncertainties that could cause actual results to differ materially from those projected. Factors that could cause or contribute to such differences include, an inability to duplicate the clinical trials or nonclinical results demonstrated in clinical studies, timely development of any potential products that can be shown to be safe and effective, receiving necessary regulatory approvals, difficulties in manufacturing any of the Company's potential products, inability to raise the necessary capital and the risk factors set forth from time to time in CEL-SCI's filings with the Securities and Exchange Commission, including but not limited to its report on Form 10-K/A for the year ended September 30, 2019. The Company undertakes no obligation to publicly release the result of any revision to these forward-looking statements which may be made to reflect the events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.

* Multikine (Leukocyte Interleukin, Injection) is the trademark that CEL-SCI has registered for this investigational therapy, and this proprietary name is subject to FDA review in connection with the Company's future anticipated regulatory submission for approval. Multikine has not been licensed or approved for sale, barter or exchange by the FDA or any other regulatory agency. Similarly, its safety or efficacy has not been established for any use. Moreover, no definitive conclusions can be drawn from the early-phase, clinical-trials data involving the investigational therapy Multikine. Further research is required, and early-phase clinical trial results must be confirmed in the Phase 3 clinical trial of this investigational therapy that is in progress.


View source version on businesswire.com: https://www.businesswire.com/news/home/20201201005307/en/

COMPANY CONTACT:
Gavin de Windt
CEL-SCI Corporation
(703) 506-9460
www.cel-sci.com  

1645 Postings, 3248 Tage Mr.BoombasticNews! MK Phase III Update

 
  
    
2
07.12.20 15:54

19825 Postings, 2223 Tage hero_of_the_dayDie Meldung löst bis jetzt noch keine

 
  
    
3
07.12.20 16:19
Jubel- Stürme aus, nicht das es am Ende des Tages noch ins Minus geht. Mal sehen was die Herren an der NYSE heute so anstellen!  

8712 Postings, 1638 Tage VassagoCVM 12.46$

 
  
    
1
07.12.20 16:43

CVM ist zwar nicht meine Baustelle, aber da ich soeben auf einen kritischen Kommentar zu dieser Aktie gestoßen bin, möchte ich ihn nicht vorenthalten:

"Mehr Verzögerungen, Ausreden heute, tieferes Begraben der fehlgeschlagenen klinischen Phase-3-Studie. Absolut schamloses Verhalten. Wenn wir eine solide Finanzaufsicht hätten, hätte die SEC diese Aktie vor langer Zeit gestoppt. Aber nein, es ist immer noch hier und schickt ablenkende Rauchwolken in die Luft."

Quelle: https://twitter.com/adamfeuerstein/status/1335953659725803520

 

1645 Postings, 3248 Tage Mr.BoombasticA. Feuerstein

 
  
    
3
07.12.20 17:20
naja, der Feuerstein..... Es ist bekannt dass er short ist und seit Jahren bei CVM basht was das Zeug hält.
Bisher nicht sonderlich erfolgreich, siehe Chart!
Und das trotz übler Lügen etc, die er in die Welt gesetzt hat. Teilweise hat er seine Twitter Posts auch wieder gelöscht/löschen müssen.
Für mich ein ganz übler Typ, der alles andere als seriös ist. Wie ist seine Ausblidung? Hat er einen naturwissenschaftlichen Hintergrund? Oder warum konzentriert er sich auf Biotechs?
Und lustig finde ich auch, dass er die Finanzaufsicht ins Spiel bringt. Ja, da bin ich auch sehr dafür. Damit diesem Short Spiel (über 10 Mio Short) endlich mal ein Ende gesetzt wird. Ich finde das pervers und extrem verwerflich, dass man hier gegen eine Firma wettet, die an einem Medikament gegen KRBES forscht. Also wenn das nicht verboten gehört weiß ich auch nicht......
Trifft natürlich nicht nur auf CVM zu.

 

19825 Postings, 2223 Tage hero_of_the_dayDas hier ein A. F. zitiert wird

 
  
    
4
07.12.20 18:21
finde ich echt lustig, ein Scharlatan der übelsten Sorte, auch er wird CVM nicht aufhalten können.
Im Moment  +10%, das geht dann heute doch in die richtige Richtung  

1645 Postings, 3248 Tage Mr.Boombasticso langsam gehts ab hier

 
  
    
1
07.12.20 18:34
über 13,50 USD jetzt schon. Auf den Feuerstein scheint keiner mehr zu hören. Gut so. Nach der News heute wird es dem ein oder anderen Short wohl doch zu heiß und deckt sich ein? Bin gespannt wie wir auslaufen. Denke da geht noch was! Habe heute nach den News jedenfalls nochmal ne kleine Position aufgestockt.  

71 Postings, 1327 Tage inkassohenry@ Mr Boombastic

 
  
    
07.12.20 21:54
welche News?  

1645 Postings, 3248 Tage Mr.Boombastic@inkassohenry

 
  
    
1
08.12.20 00:36
Na die ich heute gepostet habe.....

@all

SK super, after hour genial
Volumen auch recht ordentlich.
Man darf sich auf morgen freuen.
Hoffe nicht dass hier schon Gewinne mitgenommen werden.
Das war erst der Anfang!
 

2088 Postings, 1642 Tage uranfaktswas gibts?

 
  
    
08.12.20 06:22

1645 Postings, 3248 Tage Mr.BoombasticCEL-SCI Announces Bought Deal Offering

 
  
    
09.12.20 09:48

19825 Postings, 2223 Tage hero_of_the_dayFür Interessierte

 
  
    
4
20.12.20 10:55
the change comes never from the big guys
https://www.youtube.com/watch?v=u0oqSJ-tARs  

71 Postings, 1327 Tage inkassohenry@hero

 
  
    
1
20.12.20 11:52
Vielen Dank für das sehr interessante Interview.
 

19825 Postings, 2223 Tage hero_of_the_day@inkassohenry

 
  
    
3
20.12.20 11:56
45min. Sonntagsfreizeit die jeder CVM - Aktionär opfern sollte, sehr beeindruckendes Interview!!  

Seite: Zurück 1 | ... | 4 | 5 | 6 |
| 8 | 9 | 10 | ... | 15  Weiter  
   Antwort einfügen - nach oben